대한민국 구강암 환자중 구강편평세포암종에서 NF-κB p65 단백질 발현
The Expression of NF-κB p65 Protein in Oral Squamous Cell Carcinoma from Korean Oral Cancer Patients
한혜련, 박원익, 정수민, 장혜옥, 배수경, 유미현,
소속 상세정보
한혜련 ( Han Hye-Yeon ) - 부산대학교 치의학전문대학원 구강병리학교실
박원익 ( Park Won-Ick ) - 부산대학교 치의학전문대학원 치과약리학교실
정수민 ( Jeong Su-Min ) - 부산대학교 치의학전문대학원 구강내과학교실
장혜옥 ( Jang Hye-Ock ) - 부산대학교 치의학전문대학원 치과약리학교실
배수경 ( Bae Soo-Kyung ) - 부산대학교 치의학전문대학원 치과약리학교실
유미현 ( Ryu Mi-Heon ) - 부산대학교 치의학전문대학원 구강병리학교실
KMID : 0829220140380060349
Abstract
Oral squamous cell carcinoma (OSCC), is the most common malignancy of oral cavity, and the sixth most frequently diagnosedcancer worldwide. This tumor type is associated with poor prognosis, and most OSCC patients are diagnosed after the cancer hasreached an advanced stage. The over expression of NF-κB p65 has been associated with OSCC progression and lymph node metastasis.
Hence, the present study analyzed the expression of NF-κB p65 in OSCC from Korean patients. Immunohistochemistry for NF-κBp65 was performed using 12 normal oral mucosas (NOM), 16 oral leukoplakia (with/without dysplasia), and 58 OSCC patients samples.
Immunoreactivity was semi-quantitatively scored and the correlation between the expression of NF-κB p65 and clinicopathologicalparameters of OSCC patients was analyzed. Immunohistochemical staining revealed that NF-κB p65 expression level increased in oralleukoplakia with dysplasia and OSCC. Moreover, the immunoexpression of NF-κB p65 appeared to be associated with age, recurrence,TNM stage, and lymph node metastasis in OSCC patients (p<0.05). These results indicated that NF-κB p65 can play a role as oncogenein OSCC. Moreover, NF-κB p65 may play an important role in both oral carcinogenesis and OSCC patient outcome. It may be consideredas another new malignant biomarker of OSCC.
키워드
Oral squamous cell carcinoma; NF-κB p65; oncogene; Biomarker
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